Brian
Ingalls
Associate Professor
Department of Applied Mathematics
University of
Waterloo
Office: MC5187
Phone: 519-888-4567 ext. 35457
Fax:
519-746-4319
Mailing Address
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
e-mail: bingalls@math.uwaterloo.ca
Textbook:
Teaching:
Research Interests:
- Applications of Systems and Control Theory to
Systems Biology:
Molecular biology is undergoing a change from a hypothesis-driven
science (in which individual hypotheses are designed and tested) to a
discovery science (in which all of the elements in a system are
simultaneously determined and described). The Human Genome Project
exemplifies the discovery approach. Once these exhaustive
observations have been performed, we are faced with the task of
reverse-engineering the system's behaviour and function. The term
"systems biology" has been coined to describe the work of the
experimentalists who collect this systemic data and the
interdisciplinary team which attempts to "decode" it. The goal of the
current research is to apply the tools of systems and control theory
in this reverse-engineering process. Contributions are being made in
two directions. The first is by adding to to the body of theoretical
results which can be applied to models of biochemical systems, for
example by providing error bounds on sensitivity calculations, or by
analysing methods of stochastic simulation. The second is by drawing
analogies between man-made and biological control systems, for
example, by comparing signal transduction networks to electrical
amplifiers, or by identifying control motifs in biological regulators.
McMaster-Waterloo Bioinformatics Initiative Workshop, Tuesday August 30, 2011 Waterloo
3rd Biennial Regional
Meeting on Nonlinear Control and its Applications May 8-9,
2008, Waterloo, Ontario
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